DIM (diindolylmethane) has been shown to help regulate and promote a more efficient metabolism of estrogen, and an optimal ratio of estrogen metabolites.*
DIM Vitex PMS Formula contains BioResponse DIM®, a unique formulation containing pure diindolylmethane, an indole. Indoles are plant compounds with health-promoting properties and are found in cruciferous vegetables such as broccoli, cabbage, cauliflower, and Brussels sprouts.* The phytochemicals in cruciferous vegetables have been shown to beneficially affect the body’s hormonal and detoxification systems, and epidemiological studies support the health benefits of consuming these vegetables.* DIM is a major active acid-catalyzed derivative of one of the phytochemicals in cruciferous vegetables, indole-3-carbinol (I3C). DIM is thought to be responsible for the health effects of dietary I3C.* DIM Vitex PMS Formula contains a stable, bioavailable form of DIM, made possible through a proprietary delivery system. The formula is co-solubilized with phosphatidylcholine and microencapsulated in starch particles.
Serving Size: 2 Capsules
Amount Per Serving
Vitamin B6 (as Pyridoxal-5-Phosphate)
25 mg
Magnesium (as Magnesium Aspartate)
50 mg
Chromium (as Chromium Picolinate)
50 µg
BioResponse DIM® (A patented Diindolylmethane complex-starch, DIM (25% min.), vitamin E (as tocophersolan) phosphatidylcholine (sunflower), silica)
150 mg
Vitex agnus-castus (Berry) Extract (Standarized to 0.5% Agnusides)
75 mg
Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine
As a dietary supplement, 2 capsules one or two times daily with meals, or as directed by a healthcare practitioner.
Research over the past thirty years has determined that healthy estrogen metabolism is closely linked to several healthy parameters in men and women, particularly some involving the breast, uterus, prostate, and other reproductive tissue.* Genetics, excess weight, poor diet, and other lifestyle factors may result in an imbalance of estrogen metabolites. Xenoestrogenic compounds, such as organochlorine pesticides, can also significantly disrupt healthy estrogen metabolism.
These estrogen disruptors alter estradiol hydroxylation metabolism producing a higher ratio of the genotoxic 16α-hydroxyestrone (16α-OHE1) to the safer and weaker estrogenic 2-hydroxyestrone (2-OHE1).* The genotoxic 16α-OHE1 can potentially disrupt several normal cellular metabolic processes.* DIM promotes the conversion of estrogen to its beneficial, protective 2-hydroxyestrone metabolites and reduces the production of genotoxic 16α-OHE1.* Modulating these aspects of estrogen metabolism, particularly the production of 16α-OHE1, may contribute to healthy aging.*
