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Supports GI Health, Abdominal Comfort and a Healthy Microflora
Six-strain Bifidobacteria combination
HMF Bifido Capsules offer six proprietary Bifidobacteria strains to support probiotic colonization in the large intestine. Bifidobacteria are normally present in the gut from birth to old age, where they play an important role in gastrointestinal health. Bifidobacteria help to mediate carbohydrate fermentation in the large intestine and contribute to the production of important short-chain fatty acids (SCFAs), including acetate and lactate. Although they are the most abundant genus present in the guts of healthy infants, Bifidobacteria concentrations decrease as individuals age, with greatest declines observed in the elderly. Clinical research suggests that Bifidobacteria supplementation can promote a healthy gut flora composition, support gastrointestinal comfort, and may have a particular role in maintaining immune function. HMF Bifido Capsules provide highly researched probiotic strains such as Bl-04, CUL-34 and CUL-20, which have been demonstrated in clinical trials to contribute to gastrointestinal and immune health.
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| Probiotic Consortium | 40 billion CFU |
| Bifidobacterium animalis subsp. (CUL-34) & Bifidobacterium bifidum (CUL-20) | |
| Bifidobacterium breve (Bb-18) | |
| Bifidobacterium animalis subsp. lactis (BI-04) | |
| Bifidobacterium longum subsp. longum (CUL-75) | |
| Bifidobacterium longum subsp. infantis (Bi-26) |
Other Ingredients: cellulose, hypromellose, stearic acid
Contains no GMOs, gluten, soy, dairy FOS, artificial colors, or flavors.
Vegan.
Take 1 capsule daily or as recommended by your healthcare practitioner.
Warning: If you have an immune-compromised condition, do not use. If you are pregnant or lactating, have any health condition or are taking any medications, consult your healthcare practitioner prior to use. If symptoms of digestive upset occur, discontinue use and consult your healthcare practitioner. This product is sealed for your protection. Do not use if box or contents are open or damaged. Store under refrigeration (below 46 degrees F). Keep out of reach of children.
CAUTION: If you are immunocompromised, consult your health professional before using probiotic-containing products.
The human intestinal tract contains more than 400 bacterial species. This microflora composition can be altered by a number of factors, including diet, occasional stress, certain medications, aging and travel. When the microflora balance is affected in the intestines, common gastrointestinal complaints can occur, including mild bloating and gas. Research suggests that supplementation with Bifidobacteria can promote a healthy gut flora composition and help support gastrointestinal and immune health.
Bifidobacteria are normally present in the gut from birth to old age. As they can be transmitted from the mothers vagina, gastrointestinal tract or breast milk, they are one of the first genera to colonize the infant gut. In fact, Bifidobacteria are the most abundant genus present in the guts of healthy infants, and are present in higher amounts in vaginally-born and breast-fed infants when compared to those who are caesarean-delivered or formula-fed. As infants consume solid foods, typically around 6 months of age, bacterial diversity in the gut expands; however, the level of Bifidobacteria falls to 30-40% and continues to decrease throughout childhood and adolescence. Bifidobacteria populations decrease further in adulthood (2-14% relative abundance), but remain stable before dropping again in the elderly. In addition to the natural reduction of microbial diversity associated with old age, the high prevalence of antibiotic use in the elderly significantly impacts the intestinal microbiota composition, further reducing Bifidobacteria levels and impacting overall health.
Bifidobacteria typically colonize the large intestine, where they help to mediate carbohydrate fermentation. As a result of their involvement in host metabolism, they contribute to the production of metabolites such as vitamins, antioxidants, polyphenols and short-chain fatty acids (SCFAs), which positively affect the gut. Acetate
and lactate are the primary fermentation end-products associated with Bifidobacteria-mediated carbohydrate metabolism. Various colonic bacteria convert these metabolites into butyrate the major source of energy for colonocytes. Butyrate further contributes to gut health by promoting the production of mucin and upper gut motility, while regulating nuclear factor kappa B (NFKB) activity. In addition, Bifidobacteria help to strengthen the epithelial barrier to further maintain gut health.
HMF Bifido Capsules provide a combination of six proprietary Bifidobacteria strains from a blend of four different Bifidobacteria species. Included in this formula are CUL-34 and CUL-20, which have been selected based on their superior adherence to the gut lining, and natural resistance to pH and bile acid.6 Double-blind, placebo-controlled trials have reported that daily supplementation with a probiotic supplement (containing CUL-34 and CUL20) significantly modulates the intestinal microflora composition, supporting a favorable gut flora. An additional randomized, double-blind, placebo-controlled trial found that daily supplementation with the same probiotic strains provided support for occasional bloating and abdominal comfort, as well as bowel motility and elimination.
Additionally, approximately 80% of the body's immunologically active cells are located in gut-associated lymphoid tissue, demonstrating an important interaction between the intestines and the immune system. Preclinical research suggests that probiotics may directly medicate the activation of immune cells, the release of cytokines, and IgA antibody-mediated responses in the mucosa.
Research suggests that Bifidobacteria may have a particular role in supporting the immune system. Preliminary research showed that a probiotic supplement containing CUL-34 and CUL-20 significantly altered the immune response, as measured by altercations in the product of the cytokines. Similarly, a clinical trial reported daily supplementation with a probiotic containing CUL-34 and CUL-20 and vitamin C provide support for upper respiratory tract health.
HMF Bifido Capsules also provide BI-04, a proprietary probiotic strain that has been investigated for its effects on immune health. In a randomized, double-blind, placebo-controlled trial, physically active adults consumed either a placebo or probiotic supplement (containing 2.0X109 CFU of BI-04) daily for 150 days. Participants recorded their physical activity and respiratory health throughout the study via a web-bases questionnaire. When compared to the placebo, daily supplementation with BI-04 significantly promoted upper respiratory immune health, demonstrating its beneficial effects on the immune system.
