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Myo-Inositol is a naturally occurring inositol isomer. It helps promote the activities of the ovaries through its role as a precursor to inositol 1,4,5-triphosphate (InsP3), which regulates menstrual cycle hormones and oocyte maturation. Myo-inositol also promotes healthy glucose metabolism through the production of inositolphosphoglycans (IPG), signaling molecules involved in insulin-dependent glucose uptake. In a clinical trial involving 42 women, participants were randomized to consume 400 mcg of folic acid alone or in combination with 4 g of myo-inositol daily for six to eight weeks. When compared to placebo, myo-inositol supplementation better promoted hormonal balance, menstrual regularity, and healthy insulin function.
| Serving Size: 1 Level Scoop (4 g) | Amount/Serving |
| Calories | 10 |
| Total Carbohydrate | 4 g |
| Myo-inositol | 4 g |
Non-GMO. Gluten Free. Dairy Free. Vegan.
In a glass, add 8 oz (250 mL) of water to 1 level scoop (1 teaspoon) of Myo-Inositol and mix. Take once daily or as recommended by your health professional.
WARNING: If you are pregnant or lactating. have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children. Use only if safety seal is intact.
Storage: Store in a cool, dry place.
Inositol is a carbohydrate compound that was originally considered part of the B-vitamin family, although it has since been re-classified as non-essential due to the body's ability to synthesize it from glucose. Inositol can be converted into nine different forms of the body, including myo-inositol and D-chiroinositol. Adult diets typically provide approximately 1 g of inositol each day, primarily in the form of myo-inositol from whole grains, seeds, and fruits.
Ovarian Function
Normal myo-inositol levels can help support healthy reproductive function, including menstrual regularity and fertility. Myo-inositol is a precursor of inositol 1,4,5-triphosphate (InsP3), a signaling molecule that regulates hormones involved in the menstrual cycle and mediates intracellular calcium release. Mammalian cells - including oocytes - have receptors for InsP3. As proper calcium signaling is necessary for oocyte maturation, decreased levels of inositol can impair calcium transport and oocyte development. Through an insulin-dependent reaction, myo-inositol can be converted into D-chiro-inositol by an enzyme present in the body; however, increased D-chiro-inositol formation in the ovary can decrease the availability of myo-inositol, which in turn reduces oocyte quality. Myo-inositol supplementation can help increase both inositol levels and calcium signaling to promote oocyte maturation. As a result of its role in oocyte development, better quality oocytes are present in follicles that contain higher myo-inositol levels.
In a randomized, double-blind trial involving 92 women, daily supplementation with myo-inositol significantly improved ovarian function and menstrual regularity. Participants were randomized to consume 400 mcg of folic acid alone or in combination with 4 g of myo-inositol daily for 14 weeks. Ovarian activity was measured through weekly blood samples that were analyzed for hormone levels, and ovarian ultrasounds were conducted at baseline and after 14 weeks. Myo-inositol supplementation significantly decreased the time to first ovulation (25 days compared to 41 days for the myo-inositol and placebo groups, respectively), increased the frequency of ovulation (70% of women in the myo-inositol group established normal ovulation cycle compared to only 13% in the placebo group), and elevated the level of estradiol - a marker of follicular maturation - within the first eight days. In addition to normal ovulation frequency, myo-inositol supplementation was also associated with the promotion of hormonal balance, including a significant decease in testosterone and free androgen levels. In a similar study, total and free serum testosterone levels decreased by 66% and 73%, respectively, after six to eight weeks of myo-inositol supplementation.
Glucose metabolism
Inositolphosphoglycans (IPG) are signaling molecules that activate enzymes involved in insulin-dependent glucose uptake. IPG can be formed from D-chiro-inositol, although this conversation can be impaired due to a decrease production of D-chiro-inositol from myo-inositol or an increased excretion of inositol in the urine. Supplementation with myo-inositol increases inositol and IPG levels to support healthy glucose metabolism. Myo-inositol also helps to produce and stimulate phosphoinositide 3-kinase, which activates GLUT4 glucose transporters.
Myo-inositol and D-chiro-inositol supplementation
The uptake of both myo-inositol and D-chiro-inositol in most tissues is dependent upon the membrane-associate sodium dependent inositol co-transporter. As myo-inositol has approximately 10 times more affinity for this transporter than D-chiro-inositol, it is significantly better absorbed. Research also demonstrates that myo-inositol supplementation may better improve certain metabolic and hormonal markers when compared to D-chiro-inositol. In a double-blind study involving 60 women, participants were randomized to consume 400 mcg of folic acid with 4 g of either myo-inositol or D-chiro-inositol daily for six months. In comparison with D-chiro-inositol, supplementation with myo-inositol significantly better promoted hormonal balance - including total testosterone levels and the ratio of luteinizing hormone to follicle stimulating hormone and promoting healthy insulin function.
