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Support for Mood, Methylation, and Healthy Joints
SAM-e delivers 200 mg of S-adenosyl-methionine in acid-resistant capsules that provide both protection and pH-targeted release in intestinal fluid. SAM-e is a methyl donor in the methylation reactions shown to form monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine. Human studies show SAM-e supports positive mood and healthy central nervous system function.
SAM-e vegetarian capsules may be a useful nutritional supplement for individuals desiring support of mood, joints, methylation, or liver health.
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| SAMe (S-adenosylmethionine from S-adenosyl-L-methionine disulfate tosylate) | 200 mg |
Other Ingredients: Capsule (hydroxypropyl methylcellulose, gellan gum, water), microcrystalline cellulose, calcium oxide, ascorbyl palmitate, calcium chloride.
Does Not Contain: Yeast, wheat, gluten, soy, milk/dairy, corn, sodium, sugar, starch, artificial coloring, artificial preservatives, or genetically modified organisms (GMOs).
As a dietary supplement, adults take 1 capsule, 1-2 times daily between meals or as directed by your healthcare professional.
Warning: If you are pregnant or nursing, or if you are taking prescription medications, consult your healthcare professional before using this supplement. No adverse side effects have been reported. Keep out of reach of children.
Storage: Store in a cool, dry place, away from direct light.
SAM-e (S-adenosyl-methionine) is a naturally occurring molecule derived from the amino acid methionine. SAM-e has been shown to be efficacious in supporting numerous aspects of health. SAM-e, as a methyl donor, participates in a wide variety of biochemical reactions, acts as a precursor molecule for glutathione and polyamine synthesis, and supports healthy functioning of neurological processes, joints, and the liver. SAM-e is a methyl donor in the methylation reactions shown to form monoamine neurotransmitters such as dopamine, serotonin and norepinephrine. Human studies show SAM-e supports a positive mood and healthy central nervous system function. SAM-e is also essential to the development of the phospholipid bilayer that makes up the outer membranes of normal cells by contributing to phosphatidylcholine production and cellular membrane fluidity and integrity.
SAM-e’s joint support lies not only in its ability to help regulate the body’s normal physiological processes, but also on its putative participation in proteoglycan synthesis and joint cartilage synthesis. SAM-e is thought to function physiologically as a signal of sulfur availability. Some suggest that supplemental S-adenosylmethionine may compensate for the decreased SAM-e levels in chondrocytes induced by the cytokine interleukin-1, and thus upregulate the chondrocyte’s synthesis of joint proteoglycans. A randomized control study of 56 participants taking SAM-e offered statistically significant results for joint comfort.
As a liver health compound, SAM-e has been shown to support the body’s response to adverse biochemical alterations induced by lead and/or alcohol exposure. SAM-e can be an integral part of a liver support regimen by supporting glutathione levels. Human studies indicate that SAM-e supplementation enhances glutathione production in hepatic tissue and red blood cells.
